GASTROINTESTINAL ANGIECTASIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A MATCHED CASE-CONTROL STUDY Running title: Angiectasia and chronic kidney disease - Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation
Article Dans Une Revue Clinics and Research in Hepatology and Gastroenterology Année : 2024

GASTROINTESTINAL ANGIECTASIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A MATCHED CASE-CONTROL STUDY Running title: Angiectasia and chronic kidney disease

Résumé

Background and study aims

Chronic kidney disease (CKD) is a well-known risk factor of gastrointestinal angiectasia (GIA).

The aim was to compare this population with CDK patients without GIA.

Methods

Patients followed in the Nephrology Department of Tenon Hospital for which an endoscopy was performed between 2012 and 2022 were identified. Those with at least one GIA lesion were included ("GIA+" group). A matched control group for age, sex and GFR stage of patients with CKD and no GIA lesion ("GIA-" group) was constituted. A subgroup analysis compared patients with (SB+) and without (SB-) small-bowel involvement.

Results

A total of 55 patients were included in the GIA+ group. 36.3% (n=20) were active smokers and 29.1% (n=16) had peripheral arterial disease versus 16.4% (n=9) (OR 2.89, p=0.03), and 9.1% (n=5) (OR 4.05, p=0.015) in the GIA-group. Thirteen patients (23.6%) had a SB lesion.

Duodenal involvement was present in 69.2% of cases in the SB+ group versus 28.6% in the SBgroup (p=0.02). Median number of endoscopies, hemostatic technics and hospitalizations was 7, 3 and 6, versus 2 (p=0.0001), 1 (p=0.001) and 1 (p=0.0002) in the SB-group.

Conclusions

CKD patients with GIA had a greater cardiovascular risk with a higher incidence of vascular nephropathy. Small-bowel GIA were associated with a higher morbidity.

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Dates et versions

hal-04694487 , version 1 (11-09-2024)

Identifiants

Citer

Sarah Azancot, Xavier Dray, Parastou Moshiri, Adil Soualy, Antoine Guilloux, et al.. GASTROINTESTINAL ANGIECTASIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A MATCHED CASE-CONTROL STUDY Running title: Angiectasia and chronic kidney disease. Clinics and Research in Hepatology and Gastroenterology, 2024, 48 (8), pp.102454. ⟨10.1016/j.clinre.2024.102454⟩. ⟨hal-04694487⟩
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